Network Pharmacology Study to Interpret Signaling Pathways of Ilex cornuta Leaves against Obesity

Ilex cornuta Leaves (ICLs) are a representative and traditional prescription for controlling obesity. Nevertheless, the corresponding therapeutic compounds related pharmacological mechanisms of such medication remain undocumented. The from ICLs were identified by gas chromatography-mass spectrum (GC-MS), SwissADME confirmed their physicochemical properties. Next, target proteins to or obesity-associated retrieved public databases. RPackage constructed protein–protein interaction (PPI) network, bubble chart, signaling pathways–target proteins–compounds (STC) network. Lastly, molecular docking test (MDT) was performed evaluate affinity between ligands ICLs. GC-MS detected total 51 databases 219 associated with selective compounds, 3028 obesity-related proteins, 118 overlapping proteins. Moreover, STC network revealed 42 22 pathways, 39 which viewed be remedially significant. NOD-like receptor (NLR) pathway considered key chart. In parallel, MDT three (IL6, MAPK1, CASP1) on NLR four against Overall, might show anti-obesity synergistic efficacy inactivating pathway.